MaxxiFlex Plus
Dog Joint Supplement Ingredients

MaxxiFlex Plus uses the best key dog joint supplement ingredients in the right proportion to support and maintain bone, cartilage, and connective tissue health.

All the ingredients in MaxxiFlex Plus are of premium quality and from trusted suppliers. All raw material is quarantined upon receipt. The material goes through number of quality tests, including checking the freshness, purity, and potency, before being released for manufacturing.

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Active Vs. Inactive Ingredients

All drugs and supplements have both active and inactive ingredients. The active ingredients are the chemically active substances that produce the desired effects in the body. While inactive ingredients (or excipients) can support the active ingredients in various ways, e.g. by facilitating absorption, or be for coloring and flavoring purposes.


The Best Dog Joint Supplement Ingredients

Various studies (on humans and animals) have shown that some active ingredients support joint health better than others do. Then there are ingredients that are commonly believed to be beneficial but do not have satisfying studies to support their efficiency.

MaxxiFlex front bottle with tablets

The best know supplements for joint health are Glucosamine, Chondroitin, and Hyaluronic Acid (Sodium Hyaluronate). Glucosamine helps maintain joint mobility and relieve joint pain, Chondroitin Sulfate provides connective tissue support and protects the cartilage, and Hyaluronic Acid give elasticity to joint and is important for tissue hydration, lubrication and cellular function.

Studies have shown better result of using Glucosamine and Chondroitin together, i.e. compared to using either substance on its own. For maximum results, high quality dog joint supplement should also include Hyaluronic Acid.

There are also many other active ingredients that have been shown to be beneficial for dog joint health. Like Methylsulfonylmethane (MSM) which is important for connective tissue support and cartilage health. Cetylated Fatty Acids supports joint and connective tissue health and Bio Active Whey protein supports joint health by balancing immune and gut function. While antioxidants, like Calcium Ascorbate, can reduce free radicals, as well as minimize stress associated with great physical activity. 

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Studies have also shown that many herbs and botanical extracts can provide tissue support and help sustain healthy joints and muscle tissue. These include Turmeric extract, a powerful antioxidant that can help decrease swelling and inflammation, Bromelain that can help ease pain and swelling and support recuperation and Devil's Claw, which has a long history of use as an anti-inflammatory and modern research has confirmed its effectiveness.

MaxxiFlex Plus List Of Ingredients

These are all the active ingredients in MaxxiFlex Plus listed in the same order as on the bottle, or the highest amount in milligrams (mg) first. Just click on the ingredients you are interested in to find out more about them.

Active Ingredients Per 2 Tablets   Potential Benefits
Glucosamine HCL                     (shellfish source) 720 mg   Maintain joint mobility, rebuild cartilage, relieve joint pain, and reduce joint inflammation
Chondroitin Sulfate                    (bovine source) 250 mg   Protect existing cartilage, repair damaged cartilage, mild anti-inflammatory effect 
Hydrolyzed Collagen 250 mg   Protect / increase lean muscle mass, help improve the symptoms of arthritis
Methylsulfonylmethane (MSM) 200 mg   Source of sulfur for cartilage health, anti-inflammatory benefits
Fructooligosaccharides 170 mg   Better absorption of calcium, magnesium, and iron, better bone density and strength
Bio Active Whey 150 mg   Supports joint health by balancing immune and gut function
Devil's Claw Extract 100 mg   Anti-inflammatory, relieves arthritis pain
Phellodendron Tree Extract 50 mg   Reduce swelling / inflammation
Cetylated Fatty Acids 50 mg   Support joint and connective tissue health
DL Phenylalanine 50 mg   Help with chronic pain
Bromelain 25 mg   Anti-inflammatory, ease pain and swelling
Calcium Ascorbate 20 mg   Antioxidant, supports long-term bone health
Sodium Hyaluronate (Hyaluronic Acid) 20 mg   Joint lubrication, shock absorber
Super Oxide Dismutase 10 mg   Anti-inflammatory
Turmeric Extract 10 mg   Antioxidant, decrease swelling / inflammation

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Are Dog Joint Supplements Safe For Dogs?

Unfortunately, there is no official recommended dosage of any ingredients for dog supplements. However, all ingredients in MaxxiFlex Plus fall within the range that is considered safe for dogs' consumption.

Molly carrying ball on the beach

All drugs and supplement have potential side effects but the risk of adverse side effects of using dog joint supplement is considered extremely low. Occasionally dog may get mild stomach upset when on the high initial dose. Reducing the dose or give it with food is usually enough to alleviate the problem.

There are though circumstances where you should not give your dog any supplement without consulting your Vet first:

- If your bitch is pregnant or nursing
- If your dog has any existing health issues, e.g. related to liver and kidney function, or if your dog has stomach ulcer or diabetes
- If your dog is taking any NSAID medication 

Glucosamine HCL

Core function: Maintain joint mobility, rebuild cartilage, relieve joint pain, and reduce joint inflammation.

What Is Glucosamine?

Glucosamine is a chemical compound that is produced naturally in the body. It's found in the fluid around the joints and is important building block for cartilage. It helps cartilage to act as a shock absorber. 

Glucosamine comes in different forms, most commonly as Glucosamine Hydrochloride (HCL / HCl), Glucosamine Sulfate, and N-Acetyl-Glucosamine. The first two forms are most commonly used as canine Glucosamine but Glucosamine HCL is the highest quality, purest form of Glucosamine.

"Glucosamine hydrochloride (HCl) and glucosamine sulfate both work equally well in the cat and dog. The sulfate form was originally used in Europe. The HCl form has recently become more popular because it is purer and provides more available glucosamine per unit weight and contains much less residual ash" (MedicAnimal)

MaxxiFlex Plus includes high strength human grade Glucosamine Hydrochloride (HCL) for maximum effect.rotate-dragging-kid.jpg

The Source Of Glucosamine For Dogs

There aren't any natural food sources of Glucosamine. Glucosamine supplements are derived from chitin, substance found in the shells of shrimps, lobsters, and crabs. It can also be made in a laboratory.

The Glucosamine in MaxxiFlex Plus comes from shellfish source.

The Benefits Of Glucosamine Hydrochloride For Dogs

The cartilage acts as a shock absorber (cushion) for the joints, i.e. provides smooth surface between the bones to eliminate painful bone-on-bone contact. Over time, normal wear and tear can erode the cartilage, causing joint pain and

Dogs with arthritis (estimated around 20% of dogs) suffer most as the cartilage can degrade to the point that the bones come into contact with each other. This is very painful and can seriously limit the dog's movements.

Glucosamine is the key building block for making cartilage and taking Glucosamine supplement may help to supply the materials needed to rebuild the cartilage. Other Glucosamine benefits include anti-inflammatory effects, as it may prevent swelling and inflammation in the joints (common in dogs with arthritis).

Chondroitin Sulfate

Core function: Protect existing cartilage, repair damaged cartilage, mild anti-inflammatory effect.

What Is Chondroitin Sulfate?

Chondroitin Sulfate is the major glycosaminoglycan (group of compounds) found in cartilage. Chondroitin attracts fluid inside the joints, helping to ensure adequate shock absorption and nourishment of the tissues that line the joint.

The Source Of Chondroitin For Dogs

Chondroitin for dogs includes either bovine or shark cartilage but animal cartilage is the only dietary source of Chondroitin. Both are equally effective but using shark cartilage is not recommended as it poses threat to the integrity of the world's oceans.

The Chondroitin used in MaxxiFlex Plus includes bovine cartilage.

The Benefits Of Chondroitin For Dogs

Like Glucosamine, Chondroitin for dogs may inhibit the production of inflammatory mediators that are destructive to the joint.

"Chondroitin sulfate may actually help the body to repair damaged cartilage and help restore joint integrity. It may also protect existing cartilage from premature breakdown as well as keep cartilage tissue hydrated and assist in cushioning impact stress" (petMD)

The body's Chondroitin production decreases with age. Dog joint supplement with Chondroitin are therefore considered especially helpful for older dogs with arthritis. 

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Glucosamine and Chondroitin for dogs are frequently used together as they are considered to improve each substance's beneficial effects. MaxxiFlex Plus includes high strength human grade Chondroitin Sulfate combined with Glucosamine HCL.

Hydrolyzed Collagen

Core function: Protect / increase lean muscle mass, help improve the symptoms of arthritis.

What Is Hydrolyzed Collagen?

Collagen is the main structural component of connective tissue (cartilage, ligaments, tendons, bones, skin). It helps the connective tissue to withstand great force without breaking down or tearing. Collagen is the most abundant protein in mammals (25-30%) but the body's ability to produce and maintain collagen progressively declines after we reach adulthood.

Hydrolyzed Collagen is a modified form of collagen that is easier for the body to digest and absorb. It is composed of small amino acids and helps to form new collagen in the body.Brochure, Report, MaxxiFlex, Joints

The Benefits Of Hydrolyzed Collagen For Dogs?

There are various claims about the health benefits of hydrolyzed collagen. What matters for dogs joint health is its potential ability to protect (and even increase) lean muscle mass and to help improve the symptoms of arthritis.

There are Clinical Studies available that show that oral ingestion of hydrolyzed collagen decreases joint pain and increases bone mass density (as well as various other potential health benefits). Other clinical trials have yielded mixed results. 

Methylsulfonylmethane (MSM)

Core function: Source of sulfur for cartilage health, anti-inflammatory benefits.

What Does MSM Mean?

The full name for MSM is Methylsulfonylmethane, a naturally occurring sulfur (sulphur) compound found in the body. MSM is the source of sulfur in the body but sulfur is essential chemical needed for the synthesis of cartilage.

The Source Of MSM For Dogs

MSM is found in variety of foods, like meat, fish, eggs, milk and to a lesser amount in fruits and vegetables. Some MSM is lost during storage and food preparation and the amount of MSM decreases with age, meaning supplementing MSM may be required.

MSM is often included in dog joint supplements containing Glucosamine and Chondroitin.

The Benefits Of MSM For Dogs

The cartilage in a dog with arthritis has about one third of the concentration of sulfur when compared to healthy cartilage. MSM is therefore highly beneficial for arthritic dogs as it provides sulfur used by the cartilage in the healing process. It may have anti-inflammatory benefits as well.


Core function: Better absorption of calcium, magnesium, and iron, resulting in better bone density and strength.

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What Is Fructooligosaccharides

Fructooligosaccharides (FOS) are made up of plant sugars (fructose) that are linked together in chains. FOS is found naturally in asparagus, onions, banana, wheat, garlic, soybeans, artichoke, tomatoes and other fruits, vegetables and grains. It can also be manufactured in laboratories.

The Benefits Of Fructooligosaccharides For Dogs?

Fructooligosaccharides are best known for stimulating beneficial flora growth in the digestive tract, i.e. acting as a prebiotic.

Recent Studies have shown that FOS is also ideal for maintaining mineral density and bone strength. It increases mineral content in the bones and supports joint health, i.e. through better absorption of calcium, magnesium, and iron.

Bio Active Whey

Core function: Supports joint health by balancing immune and gut function.

What Is Bio Active Whey Protein?

Whey Protein is a mix of globular proteins that are isolated from whey (the liquid by-product of cheese production).

The Benefits Of Bio Active Whey

Bio Active Whey protein supports joint health by balancing immune and gut function. Some preclinical studies in rodents have suggested that whey protein may possess anti-inflammatory  properties as well (Wikipedia).

Devil's Claw Extract

Core function: Anti-inflammatory, relieves arthritis pain.

What Is Devil's Claw?

Devil's Claw is herb, native to southern Africa. It contains iridoid glycosides, components believed to have strong anti-inflammatory effects. 

The Benefits of Devils Claw For Dogs?

Devil's Claw has a very long history of use as an anti-inflammatory and modern research has confirmed its effectiveness. Devil's Claw has repeatedly shown to be statistically significant in reducing pain experienced by people with osteoarthritis. Most animal studies also support the anti-inflammatory and analgesic effects of Devil's Claw extracts. 

Actually few joint supplement ingredients have been shown to be as effective as Devil's Claw. Today, it is widely used to fight inflammation or relieve pain in arthritis in both humans and animals.Action, maxxiflex

Phellodendron Tree Extract 

Core function: Reduce swelling / inflammation.

What Is Phellodendron Tree Extract?

Phellodendron is a plant which bark has been used in medicine to treat various health problems, including osteoarthritis.

How Does Phellodendron Tree Extract Work? What Are Cetylated Fatty Acids?

Some chemicals in Phellodendron may reduce redness and swelling (inflammation).

Cetylated Fatty Acids


Core function: Support joint and connective tissue health.

What Are Cetylated Fatty Acids?

Cetylated Fatty Acids are a group of naturally occurring fats that support joint and connective tissue health.

How Do Fatty Acid Supplements For Dogs Work?

Cetylated fatty acids may help lubricate joints and muscles, soften tissues, and increase flexibility. It may also help the immune system and reduce inflammation / swelling (WebMD).

DL Phenylalanine

Core function: Help with chronic pain.

What Is DL Phenylalanine (DLPA)?

Phenylalanine is an amino acid, a “building block” of protein. There are three forms of Phenylalanine: L-Phenylalanine (the natural form found in proteins), D-Phenylalanine (a mirror image of L-Phenylalanine that is made in a laboratory), and DL-Phenylalanine (a 50/50 combination of the other two forms).

How Does Phenylalanine Work?

Phenylalanine has long been used to treat various health problems, including chronic pain, osteoarthritis, and rheumatoid arthritis. There are insufficient evidences for its efficiency, but considered worth including it as it may help.


Core function: Anti-inflammatory, ease pain and swelling.

What Is Bromelain?

Bromelain is an enzyme that occurs naturally in pineapple. As a supplement, it's mainly used to ease pain and swelling.Action, maxxiflex

The Benefits Of Bromelain For Dogs?

Bromelain is thought to be useful for a variety of conditions. It has been shown to be anti-inflammatory and been used to treat inflammatory conditions like arthritis. Bromelain seems to cause the body to produce substances that fight pain and swelling (inflammation).

Calcium Ascorbate

Core function: Antioxidant, supports long-term bone health.

What Is Calcium Ascorbate?

Calcium Ascorbate is a compound made up of ascorbic acid also known as vitamin C and calcium. Calcium Ascorbate is commonly used as an antioxidant, preservative, and source of vitamin C.

The Benefits Of Calcium Ascorbate For Dogs?

Calcium supports long-term bone health and vitamin C boosts the immune system. Taking vitamin C on its own can however deplete the calcium stores in the body, making Calcium Ascorbate good ingredient in dog joint supplement.

Sodium Hyaluronate (Hyaluronic Acid)

Core function: Joint lubrication, shock absorber.

What Is Hyaluronic Acid?

Sodium Hyaluronate, also known as Hyaluronic Acid, is a natural substance found in the body with the highest concentrations in the fluids in the eyes and joints.

The Benefits Of Hyaluronic Acid For Dogs

Hyaluronic Acid works by acting as a cushion (shock absorber) and lubricant in the joints and other tissues. It gives elasticity to joints, is important for tissue hydration, lubrication and proper cellular function.

Brochure, Report, MaxxiFlex, Joints

Super Oxide Dismutase

Core function: Anti-inflammatory.

What Is Super Oxide Dismutase?

Super Oxide Dismutase (SOD) is an enzyme found in all living cells. An enzyme is a substance that speeds up certain chemical reactions in the body. 

What Are The Benefits Of Super Oxide Dismutase For Dogs?

Super Oxide Dismutase is an enzyme that helps break down potentially harmful oxygen molecules in cells. This may prevent damage to tissues.

SOD has powerful anti-inflammatory activity. It has been used for the treatment of soft tissue inflammation in horses and dogs, human inflammatory diseases, and chronic bladder inflammations.Action, maxxiflex

Turmeric Extract

Core function: Antioxidant, decrease swelling / inflammation.

What Is Turmeric Extract?

Turmeric is a plant. Turmeric is best known as the main spice in curry but the root of Turmeric is also used to make medicine.

The Benefits Of Turmeric Extract For Dogs?

Whole Turmeric possesses anti-inflammatory properties. Much of this observed activity seems to be due to the presence of Curcumin, which also acts as a powerful antioxidant.

Turmeric Extract has very powerful antioxidant effects. The chemicals in turmeric may decrease swelling (inflammation). Some research has shown that taking turmeric extracts can reduce the pain caused by osteoarthritis of the knee. In one study, Turmeric worked about as well as Ibuprofen for reducing pain (WebMD).

In animal models, Curcurmin has been found to have anti-inflammatory effects in arthritic pets comparable to the NSAID drug Phenylbutazone (The Natural Health Bible for Dogs & Cats by Dr. Shawn Messonnier DVM).

MaxxiFlex Plus bottles from three sides


It Is All About The Ingredients

Supplements are all about the ingredients. Which is why we guarantee that all the above ingredients are present in the product at the date of manufacturing. We do not accept any manufacturing batch unless it conforms to all product specifications.

The photo shows a MaxxiFlex Certificate of Analysis for a specific manufacturing batch. It shows that MaxxiFlex Plus conforms to all product specification (physical, analytical and microbiological).


If you like to see the Certificate of Analysis for any specific batch, just Contact Us with the lot number and we will send you a copy.

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